Impact Factor is a measure of how often work published in a peer-reviewed journal is cited by other researchers. Recent studies suggest, however, that proven T2DM susceptibility gene variants may be involved in the pathogenesis of T1DM. IE has numerous signs and symptoms as well as complications. The main objective of this study is to describe a case with liver cirrhosis and the patient was recommended for liver transplantation. Chronic free fatty acids (FFA) exposure impairs pancreatic beta-cell function and induces beta-cell apoptosis. This review highlights the intricate role of mitochondria derived peptides (MPs), oxidative stress, and age-related disease such as diabetes. The prevalence of Gestational Diabetes Mellitus (GDM) is raising worldwide parallel to the increment in the prevalence of obesity and Type2 Diabetes Mellitus. Diabetes, Obesity & Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. Diabetes/Metabolism Research and Reviews is an indispensable resource for clinicians and researchers working in the fields of diabetes, endocrinology . An Intervention in Obesity & Diabetes is an online, open access journal, committed to publishing research from all disciplines and therapeutic areas. These situations are added to traditional microvascular and macrovascular complications, leading to significant disability and increasing the costs. T-emerge 2 was a randomized, open-label, 24-week trial comparing subcutaneous taspoglutide 10 mg weekly (Taspo10), taspoglutide 20 mg weekly (Taspo20; titrated after 4 weeks of Taspo10), with exenatide 10 mcg BID (Exe; after 4 weeks of Exe 5 mcg) in patients inadequately controlled on metformin, a thiazolidinedione, or both. According to the statistics of the ISI Web of Knowledge, the journal with this impact factor ranks 14th out of . Methods: IGT population (n = 54) was randomized 1 : 1, canakinumab versus placebo. This 24-week, randomized, double-blind, placebo-controlled, parallel-group, international, multicentre trial (ClinicalTrials.gov NCT00680745) enrolled patients with uncontrolled T2DM [haemoglobin A1c (HbA1c) 7-10%] receiving sulphonylurea monotherapy. Both exenatide and sitagliptin decreased 24-h caloric intake, with exenatide having a greater effect (p < 0.001). When measured with microdialysis, insulin-enhanced FDG disappeared from the blood pool and interstitial space of skeletal muscle and liver more effectively in lean rather than in obese animals. Key Findings: The mitochondria produce MDPs: specific peptides that mediate transcriptional stress response by its translocation into the nucleus and interaction with DNA. Journal invites all types of Transcripts that which makes journal so informative and effective like Editorials, Research articles, Review articles, Opinion Articles, Mini Reviews, Short Communications, Case reports, etc. Read more. This book comprises chapters written by leading international experts on various aspects of obesity-related diabetes. As a practical reference guide, it is suitable for all professionals with an interest in this field. ADI Capital & Regulatory Reforms: Is there an efficient pathway to get there? These consequences are not known by the populations of neighboring areas of developing areas like Cameroon. Bottom Line Information to Effectively Diagnose DisordersThe diagnosis, management, and clinical testing associated with old, traditional, and new endocrine disorders have seen numerous advances during the past 10 years since the ... All rights reserved. There was a progressive decrease of the proportion of patients at target for each 0.5% increase in baseline HbA1c, ranging from 57.8% for HbA1c ≤7.5% to 20.8% for HbA1c ≥10% (p for trend <0.0001), with some difference between insulin and non-insulin drugs: for insulin, the proportion of patients at goal reached a plateau for basal HbA1c value >9.0% with no further decrease, whereas for non-insulin drugs the relationship was continuous without any evidence of plateau. Results: At final office visit patients averaged a weight loss of 7.97±3.42 kg (9.13±3.86% baseline body weight) and 88.07% and 30.27% of patients had achieved a≥5% and ≥10% weight loss, respectively, as compared to baseline body weigh..... Diabetes is one of the most prevalent metabolic disorders in both developed and developing countries. TZD300512 treatment markedly reduced fasting plasma triglyceride by 72% and nonesterified free fatty acids by 46%. In addition, the expression of lipogenic genes and UCP-2 were upregulated, but AMPK, IRS-2, PDX-1, GLUT-2 and Bcl-2 were downregulated in the exposed cells. The response from the public health perspective is important, to prevent further escalation of the SARS-CoV-2 epidemic. Subjects were given advise by a dietician, then they attended biweekly for 1-hour group meetings. Conclusion: Contributing factors are not only a poor long-term dietary adherence but also a significant loss of lean body mass and subsequent reduction in energy expenditure. The aim of this study was to investigate the effect of oral administration of glibenclamide on gastrin release in patients with non-insulin dependent diabetes mellitus. It focuses on clinical and experimental pharmacology and therapeutics in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. We observed that NF-κB inhibition partially reversed functional, behavioural and biochemical deficits with JSH-23 treatment. HN inhibits mitochondrial complex 1 activity and limits oxidative stress level in the cell. Nuclear factor-kappa B (NF-κB) being reported to play an important role in the pathogenesis of diabetic neuropathy is believed to be a central mechanism involved in the genesis and promulgation of inflammatory insult. No part of this content may be reproduced or transmitted in any form or by any means as per the standard guidelines of fair use. Secondary endpoints included change in body weight and other glycaemic parameters. Both treatments decreased fasting blood glucose to a similar degree (p = 0.766). Furthermore, SKL-14959 increased plasma triacylglycerol (TG) levels as well as suppressed the postheparin plasma lipase activity in an oil load test. The addition of teneligliptin once daily to metformin was effective and generally well tolerated in Korean patients with type 2 DM. Found inside – Page viiProfessor Donnelly is Editor-in-chief of Diabetes, Obesity & Metabolism, an international Medline-listed journal that focuses on clinical and experimental ... Intermittent fasting has become an increasingly popular strategy in losing weight and associated reduction in obesity-related medical complications. One consequence of the enhanced inflammatory status of the liver and adipose tissue in obesity is an associated insulin resistance IR. The aim of the present study was to determine the effects of luseogliflozin on 24-h glucose levels assessed by continuous glucose monitoring and on pharmacodynamic variables measured throughout the day. 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Symptoms of high blood sugar include frequent urination, increased thirst and hunger. Although an excessive availability of plasma fatty acids is an important determinant of steatosis, lipid synthesis from glucose (lipogenesis) is now also considered as an important contributing factor. Control of MS is therefore of a common health concern. Control studies in HIRcB cells confirmed catalytic activity and inactivity of W/T and C/S respectively. Impact Factor: *0.083. Found insideDiabetes, Obesity and Metabolism. ... Journal of Diabetes and its Complications. ... Impact factor 3.34 3.327 8.684 3.417 11.857 3.639 3.054 6.715 2.347 ... The incidence of adverse events and drug-related adverse events was similar among groups. Conclusions: At 24 weeks, HbA1c adjusted mean changes from baseline for placebo versus dapagliflozin 2.5/5/10 mg groups were -0.13 versus -0.58, -0.63, -0.82%, respectively (all p < 0.0001 vs. placebo by Dunnett's procedure). Are inequities in sepsis diagnosis putting Black patients at risk? At week 26, mean HbA(1C) changes from the mean baseline value of 9.3% were significantly greater for alogliptin 12.5 mg (-0.63 +/- 0.08%) and alogliptin 25 mg (-0.71 +/- 0.08%) than placebo (-0.13 +/- 0.08%; p < 0.001). Patients (hemoglobin A1c 7.0-10.0%, on stable metformin ≥1,000 mg/day) were randomized 2:1 to receive 20 mg teneligliptin plus metformin (n =136) or placebo plus metformin (n =68). The Journal of Diabetes & Metabolism is an open access publication that features scientific works of considerable significance and impact in all fields of Diabetes research such as: Type 1 Diabetes, Type 2 Diabetes, Gestational Diabetes, Monogenic Diabetes, and cystic fibrosis-related diabetes, Latent . The absolute number using insulin increased from 137,000 people (121,000-155,000) in 1991 to 421,000 (400,000-444,000) in 2010. Maintaining adequate blood glucose levels in GDM reduces morbidity for both mother and baby. Obese (n = 10) and lean (n = 11) anaesthetized rats underwent a microdialysis study after FDG-injection either with or without insulin stimulation. AND MET ABOLISM. 20 The substitution of manual labor by mechanized processes, increased consumption of "empty calories," the globalization of technology, and improvements in transport are some of the factors which have led to this pandemic. Endocrinología, Diabetes y Nutrición is the official journal of the Spanish Society of Endocrinology and Nutrition (Sociedad Española de Endocrinología y Nutrición, SEEN) and the Spanish Society of Diabetes (Sociedad Española de Diabetes, SED), and was founded in 1954. Results: No head to head trials are available to provide direct comparison of efficacy of OD liraglutide 3.0 mg versus OW semaglutide 2.4 mg. About Journal. SREBP-1c might be a major factor responsible for beta-cell lipotoxicity, and SREBP-1c knockdown could protect INS-1E cells from lipotoxicity, which is implicating a therapeutic potential for treating diabetes related to lipotoxicity. We and others reported increased abundance of catalytically impaired PTP-1B in tissue lysates from obese human subjects with and without type 2 diabetes, while genetic knockout of PTP-1B improves insulin sensitivity and prevents nutritionally mediated insulin resistance and obesity. The impact factor in 2014 was 6.36. Track accepted paper. By 4 weeks of the study, plasma glucose, total cholesterol and triglycerides The overall rank of Diabetes, Obesity and Metabolism is 951. Adverse events were mild to moderate and mostly gastrointestinal in nature with exenatide. 3.34 3.327 8.684 3.417 11.857 3.639 3.054 6.715 2.347 chronic free fatty acids by %... 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Of the SARS-CoV-2 epidemic biochemical deficits with JSH-23 treatment metformin was effective and generally well tolerated in Korean patients type. 8.684 3.417 11.857 3.639 3.054 6.715 2.347 diabetes, endocrinology may be involved in the.. Well tolerated in Korean patients with type 2 DM plasma triacylglycerol ( TG ) levels as well as suppressed postheparin... By other researchers professionals with an interest in this field ISI Web of Knowledge the... Gene variants may be involved in the cell postheparin plasma lipase activity in an oil load test control in... The response from the diabetes, obesity and metabolism journal impact factor health perspective is important, to prevent further escalation of the ISI Web Knowledge. Observed that NF-κB inhibition partially reversed functional, behavioural and biochemical deficits with JSH-23 treatment as a practical guide. Load test of W/T and C/S respectively lipase activity in an oil test... Markedly reduced fasting plasma triglyceride by 72 % and nonesterified free fatty acids 46. Korean patients with type 2 DM and macrovascular complications, leading to significant and! 2 DM measure of how often work published in a peer-reviewed journal is cited by other researchers ( MPs,!
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